Gene Expression and Morphogenesis (GEM-DMC2, CABD)

The Gene Expression and Morphogenesis (GEM-DMC2) aims at understanding how cells coordinate their behavior during development, homeostasis and evolution of animals to generate, sustain and modify organ form and function. GEM teams integrate analyses spanning from the genomic and subcellular to the organ and organism levels.

The Unit comprises the Department of Gene Regulation and Morphogenesis at the Centro Andaluz de Biología del Desarrollo (CABD Andalusian Centre for Developmental Biology (Seville); supported by CSIC, UPO and JA) plus Acaimo González-Reyes (Dept. Cell Biology and Biotechnology).

GEM teams have a very strong background in Developmental Genetics and Molecular Biology, and their projects make use of all major multicellular model organisms (C. elegans, Drosophila, Xenopus, Zebrafish, Medaka, and mouse). Some groups have promising projects using emerging animal models such as Mayfly, Astyanax (cavefish) and Killifish.

Research in the Unit is supported by state of the art technological platforms at the CABD. Major current strengths of the Unit are: genomic and epigenomic analysis; versatile manipulation of gene expression and function; advanced microscopy and image analysis, all applicable across multiple model organisms.

A major asset of the CABD are its technological platforms, that have been developed through the joint efforts of the CABD funding patrons (CSIC, Universidad Pablo de Olavide and Junta de Andalucía). They serve as core, state of the art technological support across most research operations. Currently these are the Advanced Light Microscopy and Image Analysis (ALMI), Functional Genomics of Aquatic Vertebrates (FGAV), Mouse Transgenesis and Genome Editing (MTGE) and Proteomics (PMiCS). The María de Maeztu program facilitated the hiring of a physicist, Alejandro Campoy, to strength of ALMI and the establishment of the latest imaging techniques such as dSTORM.

Key Facts of GEM-DCM2, CABD

Percentage of publications in first quartile journals.
Number of different multicellular models used, by a total of 13 PIs of the institution.
Core facilities (ALMI, FGAV, MTGE and PMiCS) available to users.
Number of nationalities represented, out of a total of 150 researchers.

This is an excellent communication forum to speed up the flow of ideas and expertise between Severo Ochoa and María de Maeztu institutes.

Fernando Casares

Fernando Casares

Director at GEM - CABD

Articles from Gene Expression and Morphogenesis (GEM-DMC2, CABD)